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California’s CalRx®-Branded Naloxone Now Available


WHAT YOU NEED TO KNOW: As part of Governor’s Newsom’s Master Plan for Tackling the Fentanyl and Opioid Crises, over-the-counter CalRx®-branded naloxone is now available at $24 per twin-pack.

SACRAMENTO – Today the State of California announced that CalRx®-branded over-the-counter (OTC) naloxone nasal spray, 4mg, is now available for free to eligible organizations through the state or to certain organizations for $24 per twin pack through Amneal Pharmaceuticals. This follows Governor Newsom’s announcement regarding the state’s agreement with Amneal to purchase and distribute an OTC naloxone nasal spray product through CalRx®’s Naloxone Access Initiative.

“By making naloxone widely available and affordable, we are empowering communities and saving lives,” said California Health and Human Services Agency Secretary Dr. Mark Ghaly. “This is a crucial step in our ongoing efforts to tackle the opioid crisis head-on.”

California’s partnership with Amneal to provide naloxone nasal spray at a significantly lower price is already benefiting Californians. In May, the state purchased approximately 24,000 units for the California Department of Health Care Services’ (DHCS) Naloxone Distribution Project, leading to $415,000 in savings.

WHY THIS MATTERS: The opioid crisis remains a major public health challenge, with thousands of lives lost each year due to overdoses. Naloxone is a critical tool in combating the opioid crisis, capable of reversing opioid overdoses swiftly and effectively. By making CalRx®-branded naloxone nasal spray readily accessible, California is taking a significant step toward reducing the number of opioid-related deaths and ensuring that OTC naloxone is available when and where it is needed most.

See CalRx-branded naloxone come off the production line:

ABOUT CALRX®NALOXONE: Manufactured by Amneal Pharmaceuticals, CalRx® naloxone is approved by the U.S. Food & Drug Administration and is proven effective in reversing opioid overdoses – and is affordable and accessible. At this lower cost, California can substantially bolster its supply and delivery of naloxone twin packs through the state’s Naloxone Distribution Project (NDP).  Priced at $24 per twin pack, CalRx® naloxone is an affordable option, ensuring that cost is not a barrier to access for this life-saving treatment.

Boxes of CalRx-branded Naloxone.

HOW ORGANIZATIONS CAN GET CALRX® NALOXONE: California business entities and organizations seeking to purchase CalRx® OTC naloxone HCL nasal spray, 4 mg, for $24 per box can do so by visiting CalRx®’s Get Naloxone website.Eligible entities may be able to obtain CalRx® OTC naloxone for free through the DHCS Naloxone Distribution Project. For more information, please visit the Naloxone Distribution Project website.​

More information on where to find naloxone can be found on California’s opioid response website.

HOW CALRX® IS ABLE TO OFFER THIS PRICE: CalRx® is focused on increasing the availability of essential medicines that have low, transparent pricing without the use of coupons or rebates. The main goal for the CalRx® Naloxone Access Initiative is to lower the cost of naloxone to improve accessibility for all Californians.

Amneal Pharmaceuticals demonstrated a shared vision in this regard, particularly for the accessibility of naloxone, a critical life-saving drug. The $24 price point represents a more affordable cost, while enabling a leading diversified pharmaceutical manufacturer to enter the market and promote competition. CalRx®, in its dedication to transparency, is passing along these cost efficiencies to all governmental and business entities across California. 

BIGGER PICTURE: Governor Newsom released the Master Plan for Tackling the Fentanyl and Opioid Crisis to support overdose prevention efforts like the CalRx Naloxone Access Initiative. Recently, Governor Newsom launched Opioids.CA.GOV, a one-stop-shop for Californians seeking resources around prevention and treatment.